GRADE Guidelines

TABLE OF CONTENTS 



1. What are GRADE Guidelines


GRADE guidelines (or GRADE Guidance) are official papers by the GRADE Working Group, which describe how to apply the GRADE method. Each paper must be accepted by the Group prior to publication. Papers refer to various GRADE concepts: they can introduce a concept, expand on it, or update it.


2. List of GRADE Guidelines


Below you can see the list of GRADE Guidelines. The list may not be up to date. If you are aware of a missing paper, let us know at support@gradepro.org


We also link to the relevant sections of our knowledgebase that the articles may be helpful with or refer to.

The articleThe area(s) the article refers to (with links to according Knowledgebase sections)
GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tablesTypes of questions and evidence tables
GRADE guidelines: 2. Framing the question and deciding on important outcomesCreating a management question step by step
GRADE guidelines: 3. Rating the quality of evidenceGRADEing outcomes step-by-step
GRADE guidelines: 4. Rating the quality of evidence--study limitations (risk of bias)Risk of bias
GRADE guidelines: 5. Rating the quality of evidence--publication biasPublication bias
GRADE guidelines 6. Rating the quality of evidence--imprecisionImprecision
GRADE guidelines: 7. Rating the quality of evidence--inconsistencyInconsistency
GRADE guidelines: 8. Rating the quality of evidence--indirectnessIndirectness
GRADE guidelines: 9. Rating up the quality of evidenceReasons for rating up
GRADE guidelines: 10. Considering resource use and rating the quality of economic evidenceCompleting EtD
GRADEing outcomes step-by-step
GRADE guidelines: 12. Preparing summary of findings tables-binary outcomesDichotomous outcomes
GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomesContinuous outcomes
GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendationsEtD Overview
GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strengthCompleting EtD
GRADE Guidelines: 16. GRADE evidence to decision frameworks for tests in clinical practice and public healthEtD Templates for diagnostic questions
GRADE guidelines 17: assessing the risk of bias associated with missing participant outcome data in a body of evidenceRisk of bias
GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidenceROBINS-I
GRADE Guidelines: 19. Assessing the certainty of evidence in the importance of outcomes or values and preferences-Risk of bias and indirectnessGRADEing outcomes step-by-step
GRADE guidelines: 20. Assessing the certainty of evidence in the importance of outcomes or values and preferences-inconsistency, imprecision, and other domainsGRADEing outcomes step-by-step
GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracyGRADEing outcomes step-by-step, Diagnostic questions
GRADE guidelines: 21 part 2. Test accuracy: inconsistency, imprecision, publication bias, and other domains for rating the certainty of evidence and presenting it in evidence profiles and summary of findings tablesGRADEing outcomes step-by-step, Diagnostic questions
GRADE guidelines: 22. The GRADE approach for tests and strategies-from test accuracy to patient-important outcomes and recommendationsGRADEing outcomes step-by-step, Diagnostic questions
GRADE guidelines: 23. Going from evidence to recommendations: considering resource use and modelling evidence for cost-effectivenessCompleting EtD
GRADE Guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelinesStudy design
GRADE approach to rate the certainty from a network meta-analysis: addressing incoherence[coming]
GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventionsPICO and evidence tables - introduction
GRADE guidelines 27: how to calculate absolute effects for time-to-event outcomes in summary of findings tables and Evidence ProfilesTime-to-event outcomes
GRADE Guidelines 28: Use of GRADE for the assessment of evidence about prognostic factors: rating certainty in identification of groups of patients with different absolute risks-
GRADE Guidelines: 29. Rating the certainty in time-to-event outcomes-Study limitations due to censoring of participants with missing data in intervention studiesTime-to-event outcomes, GRADEing outcomes step-by-step
GRADE Guidelines 30: the GRADE approach to assessing the certainty of modeled evidence-An overview in the context of health decision-makingGRADEing outcomes step-by-step
GRADE Guidance: 31. Assessing the certainty across a body of evidence for comparative test accuracyGRADEing outcomes step-by-step, Diagnostic questions
GRADE guidelines 32: GRADE offers guidance on choosing targets of GRADE certainty of evidence ratingsGRADEing outcomes step-by-step
GRADE guidelines 33: Addressing imprecision in a network meta-analysis[coming]

GRADE Guidance 34: update on rating imprecision using a minimally contextualized approach

Imprecision

GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions

Imprecision

GRADE guidance 36: updates to GRADE's approach to addressing inconsistency

Inconsistency

GRADE guidance 37: rating imprecision in a body of evidence on test accuracy

Imprecision,  Diagnostic questions
GRADE GUIDANCE 38: Updated guidance for rating up certainty of evidence due to a dose-response gradientDose-response gradient

GRADE guidance 39: using GRADE-ADOLOPMENT to adopt, adapt or create contextualized recommendations from source guidelines and evidence syntheses

Adolopment
GRADE guidance 40: The GRADE evidence-to-decision framework for environmental and occupational healthEtD Templates
GRADE Certainty Ratings: Thresholds Rather Than Categories of Contextualization (GRADE Guidance 41)[coming]
GRADE Guidance: Using Thresholds for Judgments on Health Benefits and Harms in Decision Making (GRADE Guidance 42)[coming]
GRADE Guidance: Update on Developing Good Practice Statements in Guidelines[coming]

GRADE Guidance 44: strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions

Study design



RELATED ARTICLES

  1. GRADEbook 
  2. GRADE Working Group 
  3. Cochrane Handbook 

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